ABC294640 CAS#：915385-81-8（游离碱）

CAS#：915385-81-8（游离碱）

描述：ABC294640，也称为 Opaganib，是一种可口服的芳基金刚烷化合物，是鞘氨醇激酶 2 (SK2) 的选择性抑制剂，具有潜在的抗肿瘤活性。 给药后，ABC294640 竞争性地结合并抑制 SK2，从而防止促凋亡氨基醇鞘氨醇磷酸化为 1-磷酸鞘氨醇 (S1P)，这是一种促生存且对免疫调节至关重要的脂质介质。 这可能最终导致细胞凋亡的诱导，并可能导致抑制过表达 SK2 的癌细胞中的细胞增殖。 

MedKoo CAT#: 205806

CAS#: 915385-81-8 (free base)

Description: ABC294640, also known as Opaganib, is an orally available, aryladamantane compound and selective inhibitor of sphingosine kinase-2 (SK2) with potential antineoplastic activity. Upon administration, ABC294640 competitively binds to and inhibits SK2, thereby preventing the phosphorylation of the pro-apoptotic amino alcohol sphingosine to sphingosine 1-phosphate (S1P), the lipid mediator that is pro-survival and critical for immunomodulation. This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2.